Pancreatic cancer vaccine shows promise in first human trial, preventing disease in high-risk patients

A new vaccine for the prevention of pancreatic cancer has shown promise in an early study at Johns Hopkins School of Medicine in Baltimore, Maryland.

A phase 1 trial published in Cancer Discovery, a journal of the American Association for Cancer Research, tested an experimental vaccine called mKRAS-VAX in 20 people, according to a press release.

Participants had an inherited risk of pancreatic ductal adenocarcinoma (PDAC), the most common and aggressive form of pancreatic cancer, along with an abnormality detected in imaging, typically a pancreatic cyst. These individuals had not been diagnosed with pancreatic cancer.

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Four injections were administered to participants during weeks one, three and five, along with a booster at week 13.

The vaccine targeted six common mutations of KRAS. Changes in this gene drive more than 90% of PDACs.

The vaccine triggered a mutant KRAS-targeted immune response in 18 of the 20 participants (90%). On average, immune activity increased about 18-fold, although responses varied. Half of participants responded to all six KRAS mutations included in the vaccine.

Researchers also found the vaccine generated two types of T cells — one to attack abnormal cells and another to provide longer-term immune memory.

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The vaccine appeared to be safe, with participants experiencing only injection-site reactions and temporary flu-like symptoms.

While the phase 1 trial was designed primarily to evaluate safety rather than effectiveness, after about 16.5 months of follow-up, no participants had developed pancreatic cancer. At the same time, 37.5% of vaccinated participants experienced shrinkage or disappearance of the pancreatic cysts that had put them at increased risk for the disease.

Study co-author Neeha Zaidi, MD, associate professor of oncology at the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, commented that the long-lasting response of this vaccine is "particularly noteworthy when assessing for possible interception of cancer, which requires long-lasting immunity."

"In addition, the vaccine was safe and well-tolerated, supporting its use in larger cancer interception studies," she said in the press release. "Overall, this study represents the first proof of concept for the use of vaccines for interception of pancreatic cancer in human patients."

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Co-author Michael G. Goggins, MD, professor of pathology, medicine and oncology and the Sol Goldman Professor of Pancreatic Cancer Research at Johns Hopkins University School of Medicine, also commented on the findings.

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"We observed evidence of stability or regression of the pancreatic cysts in association with the induction and durability of KRAS-specific T-cell responses," he said in the release. "However, larger studies are needed to demonstrate that this effect was in fact due to the vaccine."

The authors noted the study was limited by its small sample size and because it was not designed to determine clinical efficacy.

Fellow senior author Elizabeth Jaffee, MD, deputy director of the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, commented that prevention and interception "save lives and reduce the morbidity associated with cancer development and progression."

"This is especially important for cancers whose early-onset frequency is increasing and for which we do not have effective methods for early detection," she added in the release.

Jaffee noted that this research highlights the need for more funding to support developing strategies for preventing cancer in high-risk individuals.

"More studies are needed to find the best vaccine approaches, the best targets and the ideal timing for vaccination," she said.

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Michelin-star chef reveals what's replacing hospital food Americans love to hate

"Hospital food" has long been synonymous with packaged, ultraprocessed meals — despite the fact that hospitals are meant to promote healing.

In an exclusive interview with Fox News Digital at the Great American State Fair in Washington, D.C., Michelin Star chef Geoffrey Zakarian shared his initiative to improve what is served in U.S. hospitals, following the concept that "food is medicine."

For the last three years, Zakarian said he’s been working on changing hospital food — most notably at Tampa General, which is a $4 billion nonprofit, 1,000-bed public hospital.

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On Thursday, July 16, Tampa General Hospital CEO John Couris signed the "Make Hospital Food Healthier" pledge during a news conference attended by Health and Human Services (HHS) Secretary Robert F. Kennedy Jr., U.S. Department of Agriculture (USDA) Secretary Brooke Rollins and Zakarian.

The pledge commits the hospital to serving more nutritious, minimally processed meals to patients, building on Zakarian's menu overhaul.

"We’ve changed the entire menu," the celebrity chef told Fox News Digital. "We've taken all seed oils out, sugar, maltodextrin. Anything bad in a box is gone. Anything good is brought in."

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"We're serving mac and cheese. We're serving hanger steak and fries. We're serving chicken with couscous. We do all our protein shakes. No protein shakes in the box anymore. We do fruit shakes, smoothies, fresh sorbet," the chef listed. "So, you're eating like your grandmother's cooking for you."

CMS Administrator Dr. Mehmet Oz has also supported Zakarian in this mission, telling Fox News Digital that the chef has "revolutionized our thinking" around hospital food.

"How do we get the hospitals to do what [Zakarian] has been doing the frontier work on, get them to actually embrace food as part of the healing process?" he questioned. "Because most patients, and most doctors, know that the food in the hospital is not going to make you better."

Oz noted that while hospital food may provide some nutrients, it is generally not seen as contributing meaningfully to patients' recovery.

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The biggest challenge to getting better food into hospital systems has been cost, Zakarian pointed out.

While "everything is fractionalized," what’s left over after paying for supplies is put toward food, which generally "ain’t much," he said.

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"It's, like, $3.50 a person per plate, which is an extraordinarily small amount," the chef said. "You go to McDonald's and you spend 12 bucks for a happy meal, and we give you $3.50 in a hospital. So that's an unhappy meal as far as I'm concerned."

Instead of charging hospitals for each plate served, Zakarian's approach relies on a flat annual fee, saving money through a smaller, higher-quality menu.

"Yummy food, not just food to fill people up," he said. "Nutritious food, bioavailable food, food that's satiating."

"I'm cooking like I would cook in a restaurant. I'm cooking like my mother cooked for me. There's no difference."

The chef continued, "When you're lying in bed in a hospital gown, you feel alone, you feel exposed, you feel sick … When you have a fresh protein shake or a fresh healthy smoothie, or you can order steak frites ... that [makes] your day."

Freelance writer Teresa Mull contributed to this report.

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Melinda French Gates says it took 3 doctors to diagnose the condition she was suffering from

Melinda French Gates is speaking out about the challenges of recognizing perimenopause, saying she didn't receive the proper diagnosis and treatment until after seeing three different doctors.

She shared her experience with journalist Norah O'Donnell's new podcast "Healthful," which will be released on Wednesday.

French Gates, now 61, said she was in her early 40s when she began experiencing menopause symptoms, noting that she "kind of couldn't believe it," as reported by CBS News.

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Later, the philanthropist and businesswoman would learn that many OB-GYNs receive little formal training in menopause care, which she says underscores a broader gap in women's healthcare.

French Gates shared that she was lucky enough to know the signs, thanks to input from older friends.

"But it was kind of unbelievable to me that, even in this, you know, unbelievably privileged situation I'm in, where I feel like I can get some of the best healthcare, it took me three doctors to really diagnose what I was going through and to get the right treatments for where I was," she said during the interview.

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"It wasn't because anybody was doing the wrong thing. It's because of what I now know, which is, only one-third of OB-GYNs in this country are trained in menopause."

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Supporting her claim, a national survey published in the journal Menopause in 2023 found that only about one-third of U.S. obstetrics and gynecology residency programs include a formal menopause curriculum.

More recently, a 2024 study found that OB-GYN, family medicine and internal medicine residents have low knowledge and low confidence in treating menopausal symptoms.

In a separate 2026 Kansas study, more than half of residents reported receiving fewer than five hours of menopause education — and the majority did not believe that residency fully prepared them to treat menopausal patients independently.

In a national survey of 2,000 women, only 25% said their healthcare provider had adequately informed them about perimenopause.

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Additional training in this area could help, researchers claim, as knowledge scores increased from 61% to 79% among those who received a structured curriculum.

About 1.3 million U.S. women reach menopause each year, according to The Menopause Society. Most begin perimenopause in their 40s, although it can start earlier.

As perimenopause causes hormone levels to fluctuate, women can experience a range of symptoms. Some of the most common include irregular periods, hot flashes, night sweats, sleep disturbances, mood changes, vaginal dryness, brain fog and joint pain as hormone levels begin to fluctuate, according to Mayo Clinic.

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NYC Legionnaires' disease outbreak kills fourth victim, 76 cases reported

An outbreak of Legionnaires' disease in New York City killed a fourth person as 76 cases have now been reported in the city, city health authorities announced Monday.

The outbreak, which city authorities have linked to a series of cooling towers in Upper East Side buildings, has hospitalized 60 people, 53 of whom were discharged while seven remained in the hospital, according to authorities.

The fourth death announced Monday follows a first death from the disease on Friday. City officials announced two additional deaths over the weekend.

Legionnaires disease comes from live Legionella bacteria infecting a person's lungs. While, according to New York City health authorities, most people exposed to the bacteria don't get sick, infection can cause a severe form of pneumonia that can be fatal.

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"Symptoms typically develop two to fourteen days after exposure and include fever, chills, muscle aches, shortness of breath, and cough. Legionnaires’ disease can be effectively treated with antibiotics when diagnosed early," New York City's Health Department wrote in a statement.

City officials discovered the recent outbreak on July 2, and quickly tied it to a series of cooling towers in 31 different buildings in the city. 

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After testing 180 different cooling towers, the city found live or dead Legionella bacteria in 31 buildings. The city, in a statement, stressed that the discovery of dead bacteria in some buildings did not necessarily mean people in that building were ever exposed to the disease. 

The city ordered the following buildings, which includes the building that houses the vaunted Guggenheim Museum at 1071 Fifth Ave., to initiate a deep clean and disinfectant of their cooling towers "out of an abundance of caution.

City officials cautioned residents that mask wearing will likely not help stave off infection as Legionella bacteria is not transmissible person-to-person. Community cluster outbreaks like the Upper East Side one usually stem from common sources of exposure, such as "cooling towers, hot tubs, and spray fountains," the city said.

Public testing of the bacterium are ongoing, the city also announced. 

The city last experienced a major Legionnaires' outbreak in August 2025, when over 100 people in Harlem got sick and seven died. 

Fox News Digital contacted the NYC Health Department for additional comment.

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Fitness influencer Clavicular says he started taking testosterone at 14, calls natural training 'a waste'

Clavicular revealed on the "Hang Out with Sean Hannity" podcast that he abandoned natural weightlifting as a teenager in favor of taking testosterone.

On Tuesday's episode, the fitness and looksmaxxing personality – known for his controversial focus on "looksmaxxing" – called traditional training without performance-enhancing drugs a "complete waste of time."

Clavicular, whose real name is Braden Eric Peters, told Hannity that his interest in fitness began in his family's basement gym in Hoboken, New Jersey. After researching workout routines online, he decided that making progress naturally was too slow.

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"I started reading different articles and forum posts about how to properly train as one would being a beginner to the gym, and that's sort of where I came to the conclusion that there's no reason to train naturally," Clavicular said.

"It's a complete waste of my time when I have this mechanism I could utilize, which was testosterone, to make the results in a much more efficient timeline. So why wouldn't I?"

The decision led Clavicular to secretly acquire performance-enhancing drugs at a young age, he shared.

"I used to have to camp out by the mailbox and pretend to be sick from school," he said, adding that he intercepted shipments of testosterone at age 14 to hide them from his parents.

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Hannity, a father of two, pointed out that many parents would react with anger and concern, prompting Clavicular to admit that his parents disciplined him repeatedly throughout his teenage years.

"Throughout high school, if I would do a f--- up, I would get sent [to my grandmother's]," he said. "Then, after I got expelled from university for peptides and 'roids, that's where I got sent off to."

Clavicular said his academic career came to an abrupt halt after his public social media posts about his steroid use caught up with him.

"Throughout my entire life, I've kind of been documenting everything in a pretty public way," he said. "I was talking about different cycles I was running, and then someone just sent the forum posts to my university, and it was done."

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While public discussions surrounding low testosterone levels and hormone health have grown in recent years – often focusing on symptoms like fatigue, low libido and loss of muscle mass – endocrinologists and medical experts consistently warn against nonmedical androgen use.

In adolescents and young adults, unsupervised anabolic steroid and peptide usage can carry severe health risks, including stunted skeletal growth, premature cardiovascular strain, liver damage, psychiatric mood alterations and irreversible fertility suppression, according to the Endocrine Society.

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Medical professionals emphasize that while hormone therapy can be beneficial for men with legitimate medical deficiencies, using testosterone as a shortcut for muscle growth bypasses essential metabolic and biological safeguards.

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Kai Trump reveals diet and nutrition secrets that created six-pack abs post-surgery

Kai Trump is fueling her golf game with a protein-packed diet, clean meals and a disciplined fitness routine.

In an interview with Fox News Digital, President Donald Trump’s eldest granddaughter, 19, discussed how she stays healthy and fit as a college athlete, sharing that she eats "a lot of protein."

"I weigh 120 pounds and I probably eat around 150 grams of protein," she said. "[I] eat a lot of sustainable carbs and work out a lot."

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The competitive golfer, who plays for the University of Miami Women’s Golf team, said she also follows a gluten-free and dairy-free diet, and avoids eggs due to a slight allergy.

Despite her demanding schedule, Kai makes a point of fueling her body with protein-rich foods rather than skipping meals.

"No matter what I'm doing, I always have like 40 grams of protein in the morning through a shake or something, just so I have it in my system," she told Fox News Digital. "So, if I run or I'm doing something crazy, at least I had that. I got that protein in."

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The young influencer revealed that her favorite go-to dish is a ground beef bowl, which she prepares with rice, avocado and some seasonings.

"I eat very clean and simple," she said. "I would be totally fine eating steak for the rest of my life, or just chicken and rice, which is weird to some people, but I like it."

When she does decide to indulge in a "guilty pleasure" snack, Kai said she never reaches for sweets, but rather some prosciutto with pesto.

She said her mother, Vanessa Trump, who is in "great shape," helped instill the healthy habits that Kai follows today.

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"Seeing how she eats and what she prioritizes ... I kind of grew into that," she shared.

Don Trump Jr.'s oldest child said her healthy lifestyle paid off after wrist surgery temporarily sidelined her from golf. Rather than viewing the recovery as downtime, she told friends that she planned to use the time to achieve "six-pack" abs.

"I literally told them, ‘I have seven months before I return to golf, we're getting a six-pack,’" she said. "And I got a six-pack literally just by prioritizing the right foods and working out."

Kai credited that transformation to consistent workouts and a nutritious diet.

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At the gym, she follows a well-rounded routine that includes core exercises, squats and cardio on a stair-climbing machine. Before tournaments, she switches to a trainer-designed warm-up that consists of foam rolling followed by muscle activation exercises.

The president's granddaughter said she's developed many of her own fitness habits by researching what works and adapting it to fit her lifestyle.

Beyond physical fitness, the golf prodigy said it's just as important to protect mental health by taking breaks from phones, spending time with friends and enjoying hobbies.

"I play a lot of golf … and then work out," she said. "Nothing clears your head better than going to the gym and working out ... Even if you're not lifting heavy or if you're just walking on the treadmill, being active clears your head and helps your mental health."

Kai also documents her life on YouTube, where her 1.5 million subscribers follow her experiences as a competitive golfer, college student and member of the Trump family through videos featuring tournaments, travel, family moments and major public events.

Asked for her biggest wellness tip, Kai said the people you spend time with can have just as much impact as a diet or workout routine.

"If you surround yourself with the wrong people, they can drain you," she said. "At the end of the day, you are who you surround yourself with."

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Brain tumor found during preventive scan puts full-body MRIs back in the spotlight

After a former "Bachelor" contestant said a preventive scan uncovered a brain tumor before symptoms appeared, doctors are once again weighing the promise — and pitfalls — of full-body MRI screenings.

The renewed attention comes as celebrities including Kim Kardashian, Paris Hilton and now former "Bachelor" contestant Josh Seiter have publicly discussed preventive body scans, fueling consumer interest in the technology despite ongoing debate among medical experts about its benefits for healthy people.

Full-body scans use different technologies, including magnetic resonance imaging (MRI), computed tomography (CT) or positron emission tomography (PET), according to the Dana-Farber Cancer Institute.

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The goal is to detect early signs of diseases such as cancer, heart disease and other abnormalities.

Dr. Daniel Durand, chief medical officer at Prenuvo, one of the biggest U.S. providers of full-body scans, compared the scan to a "virtual physical" in which a radiologist examines the inside of the body in a way that a traditional annual physical cannot.

Prenuvo's scan uses MRI technology to collect a "vast amount of health data," the Maryland-based doctor previously told Fox News Digital.

"Two licensed providers analyze this data, explain its relevance directly to you and offer you guidance on the next steps necessary to optimize your health," he said.

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Insurance does not typically cover whole-body scans.

"Coverage usually varies widely by insurance plan, jurisdiction, and the specific clinical guidelines for each genetic condition," Dr. Mikhail Varshavski, more commonly known as "Dr. Mike," a podcaster and primary care physician in New Jersey, previously told Fox News Digital. 

"My general understanding is that for screening purposes, the test is usually not covered, given the lack of documented clinical benefit versus harms."

Some coverage may be offered, however, for those with high-risk genetic syndromes or other specific medical conditions, the doctor noted.

"Our hope is that over time, insurers will see the many benefits of our proactive approach to healthcare and will broaden coverage," Prenuvo’s Durand said.

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"We are actively engaged in several research studies that could provide a foundation for insurance reimbursement."

Depending on the provider and options selected, prices for full-body scans can be as high as $2,500.

The two biggest providers of full-body scans are Prenuvo (headquartered in California) and Ezra (based in New York City). 

Dr. Brett Osborn, a Florida neurologist and longevity expert, has also spoken with Fox News Digital about the benefits of full-body MRI scans.

"Full-body scanning, mainly through MRI, presents a significant advancement in modern medicine's diagnostic capabilities," he said.

"MRI technology allows for a comprehensive, non-invasive examination of the body to detect a wide range of conditions, including cancer and vascular malformations like aneurysms, without the need for potentially harmful radiation, as is the case with CT scans," he also said.

Durand claimed that a Prenuvo scan can detect many diseases based on changes to the inside of the body that can be detected by MRI.

"Usually these changes happen before symptoms occur or before there are signs on a physical exam," he told Fox News Digital.

"So, in many cases, the earliest signs of diseases — like cancers, infections or aneurysms — will be seen," he went on. "By seeing them earlier, you can be treated earlier, hopefully before the disease has done little to no permanent damage."

Dr. Mike told Fox News Digital that he has not recommended that any of his patients get an MRI screening scan. 

"The high upfront cost and lack of clear medical indication for broad screening (if you’re low-risk and asymptomatic) lead me to agree with the major medical organizations that routine whole-body MRI screening for the general population is not recommended," he said.

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Much of the popularity of these scans has been driven by celebrities, who sometimes receive them for free, Dr. Mike said — which he finds concerning.

"My understanding is that even receiving a free scan is a business relationship that the FTC requires disclosing," he said. "My understanding is that the companies themselves cannot claim their tests save lives, so they work with celebs who can make personal claims that are not subject to the same investigational scrutiny."

"This also sends a conflicting message to the consumer and creates confusion."

Dr. Marc Siegel, clinical professor of medicine at NYU Langone Health and Fox News' senior medical analyst, also does not recommend these scans to patients.

"With the current level of technology, I am against full-body scans in favor of more directed workups initiated by expert physicians who know what they are looking for," he has told Fox News Digital.

"If you do a full-body scan, you will be inclined to pursue every positive finding, whether they are really significant or not."

Siegel also noted the high expense and the fact that full-body scans are "frequently oversensitive."

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"They may take the place of more directed, accurate studies and screening tests that are more suited to the symptoms, history and genetic tests in specific patients," Siegel cautioned. 

The doctor also noted the current shift toward more personalized healthcare approaches, "augmented by not just genetics, but also artificial intelligence."

"This will lead to more directed workups, not to more full-body scans."

The most significant risks that come with these full-body scans, according to Dr. Mike, are the issues that arise with false positives, overdiagnosis and overtreatment.

There are also mental risks, including anxiety during the procedure (claustrophobia), stress from incidental findings and an increase in health-related worries, the doctor noted.

"Some proponents say it can ease health-related anxiety; however, I am pretty skeptical of that claim," he said. "Based on my clinical experience, even getting a clear scan would secure peace of mind only temporarily."

Research published in 2020 found that imaging abnormalities are expected in about 95% of screened subjects, according to the doctor. 

"This means the majority of those scanned will have some sort of finding presented to them," he said. "I can’t imagine how helpful that would be to someone already prone to health worries."

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During a 2025 podcast interview with Dr. Mike, Andrew Lacy, CEO of Prenuvo, said that long-term data on these screening scans is not yet available.

"So, currently, we don't know if we are saving more people by catching disease early or harming more people with overdiagnosis, false positives and overtreatment," Dr. Mike said. 

"Barring emergencies, if I don't have clear data about the harms and benefits of an intervention, especially one that is meant to be used on healthy people, I cannot widely recommend it."

Prenuvo did cite a recent study of over 1,000 patients who were followed over a one-year period.  

"In this sample, we found pathologically-proven cancer in 2.2% of Prenuvo patients," Durand told Fox News Digital. "Importantly, most of these cancers were early stage, and the majority were cancer types for which there is no widely accepted screening exam."

The most recent guidance from the FDA echoes the doctors’ concerns.

"At this time, the FDA knows of no scientific evidence demonstrating that whole-body scanning of individuals without symptoms provides more benefit than harm to people being screened," the agency stated on its website.

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The FDA also warned about the "relatively high radiation exposure" from CT scans. While this exposure risk is "greatly outweighed" by the benefits of diagnostic and therapeutic scans, the agency said that for whole-body screening of asymptomatic people, "the benefits are questionable."

"Before having a CT screening procedure, carefully investigate and consider the potential risks and benefits and discuss them with your physician," the FDA advised. 

The American Academy of Family Physicians (AAFP) also recommends against full-body scans for early tumor detection in asymptomatic patients.

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