Health

  • Home
  • Business
    • Internet
    • Market
    • Stock
  • Parent Category
    • Child Category 1
      • Sub Child Category 1
      • Sub Child Category 2
      • Sub Child Category 3
    • Child Category 2
    • Child Category 3
    • Child Category 4
  • Featured
  • Health
    • Childcare
    • Doctors
  • Home
  • Business
    • Internet
    • Market
    • Stock
  • Downloads
    • Dvd
    • Games
    • Software
      • Office
  • Parent Category
    • Child Category 1
      • Sub Child Category 1
      • Sub Child Category 2
      • Sub Child Category 3
    • Child Category 2
    • Child Category 3
    • Child Category 4
  • Featured
  • Health
    • Childcare
    • Doctors
  • Uncategorized

Monday, March 4, 2024

Cancer risk rises with this little-known syndrome. Here’s how to know if you have the genetic condition

 March 04, 2024     Health, Health News Today on Fox News     No comments   

As colorectal cancer continues to spike among younger patients, doctors are warning of a little-known but widespread condition that greatly increases the risk.

Lynch syndrome is a genetic disorder that makes someone more susceptible to many different kinds of cancer.

Fox News Digital spoke with two experts about what people should know about this inherited condition.

CANCER PREVENTION IN THE ESOPHAGUS COULD BE JUST A PILL AWAY, DOCTOR SAYS: ‘TREMENDOUS BENEFIT’

Dr. Matthew Grossman, an interventional endoscopist and gastroenterologist with Atlantic Health System in New Jersey, explained the relationship between Lynch syndrome and human DNA.

"Think of DNA as a ladder," he said. "Normally, errors in the rungs — called mismatches — are fixed by a repair system. In Lynch syndrome, this system is faulty, increasing the risk of mismatches."

Because of the mismatch repair defect, a person with Lynch syndrome is much more likely to develop abnormalities and defects in cells, which eventually lead to cancer, he said.

"Lynch syndrome is a type of germline mutation, meaning it’s inherited genetically, versus a somatic mutation, which can happen spontaneously to only a few cells," said Grossman.

DOCTORS TOLD WOMAN SHE WAS TOO YOUNG FOR A COLONOSCOPY. THEN SHE WAS DIAGNOSED WITH STAGE 3 COLON CANCER

Dr. Ajay Bansal, a gastroenterologist at KU Medical Center at the University of Kansas, emphasized that Lynch syndrome largely flies under the radar, as 95% of patients who have the condition don’t know about it.

"They are not aware that they are at increased risk for not only colon cancer, but also uterine, ovarian, stomach, small bowel, kidney, bladder and perhaps brain cancer," he told Fox News Digital. "So it's very underdiagnosed."

One of the reasons the syndrome often goes unnoticed is because it’s a "silent" condition, Bansal said. "It doesn't cause any symptoms until you have cancer."

The two main cancers tied to the syndrome are colon and colorectal cancer and cancer of the uterus.

"Lynch syndrome can result from four or five different mutations," Bansal said. "Depending on the mutation, the type of cancer risk changes."

COLORECTAL CANCER IS NOW LEADING CAUSE OF DEATH AMONG YOUNG ADULTS WITH CANCER: NEW REPORT

For example, for those who have a mutation in a gene called MLH1, the risk of getting colorectal cancer at some point in their lifetime is 80%, Bansal warned.

Among young-onset colorectal cancers, the doctor estimated that roughly 25% are a result of Lynch syndrome.

Lynch syndrome can be diagnosed by either a blood test or saliva test, Bansal said.

"If a patient has a family history of multiple colon cancers or multiple other cancers in the family, or if somebody in the family had colon cancer or uterine cancer under the age of 50, we recommend genetic testing to confirm the syndrome," he said.

Patients who fall into these categories are typically tested for Lynch between the ages of 18 to 25, the doctor said.

Universal genetic testing is not generally performed.

"It's not approved for the general population, mainly because of costs and insurance concerns," Bansal noted.

CANCER RISK COULD INCREASE WITH CONSUMPTION OF CERTAIN FOODS AND DRINKS, STUDY FINDS

Before genetic testing was available, clinicians relied on the "3,2,1 criteria" for diagnosing Lynch syndrome, according to Grossman.

"For that criteria, if patients have three or more relatives with one of the affecting cancers on the same side of the family, and this is seen in two or more generations with at least one person under age 50, that is highly diagnostic of Lynch syndrome and they should discuss the condition with a doctor," he said.

There is no treatment or "cure" for Lynch syndrome, as it's caused by a genetic mutation. 

Those who test positive should closely monitor themselves for the warning signs of cancer through regular screenings — especially colonoscopies, Bansal said.

In the general population, among people without Lynch syndrome, it is recommended to start colonoscopies at the age of 45. 

In patients with Lynch syndrome — especially those with more aggressive phenotypes and genotypes — Bansal recommended starting colonoscopies at the age of 25 and repeating them every one to two years.

"The idea here would be to monitor closely so we can prevent colon cancer by removing polyps or catching it at an early stage when we can treat it," he said.

CANCER SCREENINGS: HERE ARE 5 TYPES AND CRITICAL INFORMATION TO KNOW ABOUT EACH

Bansal, who specializes in studying vaccines for cancer prevention, is currently running a clinical trial for a new cancer vaccine. The participants are all people with Lynch syndrome.

"We felt that we had to do something to change the natural history of cancer in this high-risk population," he told Fox News Digital.

In the trial, researchers are testing a combination of three vaccines that were initially created by a scientist at the National Cancer Institute. 

"These vaccines attack those cells in the colorectal area that express abnormal proteins, and then it can train the immune cells to get rid of those cells in the colon — and perhaps in other organs such as the stomach, small bowel, pancreas and uterus — before they turn into cancer or polyps."

The first two safety phases of the trial have already been completed. 

Next, the researchers will perform randomized controlled trials to gauge the effectiveness of the vaccines in keeping cancer at bay.

CLICK HERE TO SIGN UP FOR OUR HEALTH NEWSLETTER

If the trial is successful, Bansal said he envisions the vaccine extending to other types of cancers.

Bansal’s main advice to patients is to talk to their primary care doctors about their family history.

"In medical care, everybody's so busy that we don't discuss family history enough," he said. "Patients should ask their doctor about their family history of cancers and the possibility of genetic testing, which has become much cheaper than ever before."

Grossman agreed that it's important to be aware of the risks associated with the genetic condition.

"Knowing you have Lynch syndrome allows for more frequent colonoscopies and additional cancer screenings that will help save lives," he said. 

"This is a great example of how our increased knowledge of genetics has improved our clinical care."

For more Health articles, visit www.foxnews.com/health.



from Health News Today on Fox News https://ift.tt/TWyJie3
  • Share This:  
  •  Facebook
  •  Twitter
  •  Google+
  •  Stumble
  •  Digg
Email ThisBlogThis!Share to XShare to Facebook

Related Posts:

  • FOX NEWS: Woman with massive tumors on legs faces incurable disorder Woman with massive tumors on legs faces incurable disorder A Brazilian woman who developed massive tumors on her legs caused by a rare genetic dis… Read More
  • FOX NEWS: New mom had no idea she was having twins until doctors saw a second head coming out New mom had no idea she was having twins until doctors saw a second head coming out A first-time mom from Michigan reportedly didn't know she was … Read More
  • FOX NEWS: New tech helps police find people at risk of wandering New tech helps police find people at risk of wandering Police in California use radio frequency transmitter devices to track participants at risk … Read More
  • FOX NEWS: California boy uses sled to yank out tooth California boy uses sled to yank out tooth A California boy used his sled to yank out his loose tooth. via FOX NEWS http://bit.ly/2UwMKUf … Read More
  • Woman suffering from massive tumors on legs facing incurable disorderA Brazilian woman who developed massive tumors on her legs caused by a rare genetic disorder has already undergone several surgeries to remove the gro… Read More
Newer Post Older Post Home

0 comments:

Post a Comment

Popular Posts

  • Ozempic ‘microdosing’ is the new weight-loss trend: Should you try it?
    A new trend gaining popularity among people trying to lose weight is microdosing the diabetes medication Ozempic. With approximately 70% of...
  • Helping Stroke Patients Regain Movement in their Hands
    By BY PAM BELLUCK from NYT Health https://ift.tt/6uNPHMD
  • As eating disorders increase among college students, here's how parents can help: ‘Early intervention is key’
    While most of us have heard about the "Freshman 15" — the stereotypical first-year weight gain among college students — a growing ...

Recent Posts

Categories

  • Health News Today on Fox News
  • FOX NEWS
  • Fox News : Health
  • Health
  • Health News Today on Fox News
  • Healthy tips
  • NYT

Unordered List

Pages

  • Home

Text Widget

Blog Archive

  • June 2025 (1)
  • May 2025 (88)
  • April 2025 (84)
  • March 2025 (88)
  • February 2025 (70)
  • January 2025 (72)
  • December 2024 (81)
  • November 2024 (70)
  • October 2024 (82)
  • September 2024 (75)
  • August 2024 (82)
  • July 2024 (79)
  • June 2024 (74)
  • May 2024 (73)
  • April 2024 (78)
  • March 2024 (75)
  • February 2024 (78)
  • January 2024 (78)
  • December 2023 (60)
  • November 2023 (80)
  • October 2023 (74)
  • September 2023 (75)
  • August 2023 (85)
  • July 2023 (67)
  • June 2023 (58)
  • May 2023 (100)
  • April 2023 (105)
  • March 2023 (118)
  • February 2023 (84)
  • January 2023 (87)
  • December 2022 (69)
  • November 2022 (64)
  • October 2022 (78)
  • September 2022 (74)
  • August 2022 (110)
  • July 2022 (109)
  • June 2022 (127)
  • May 2022 (95)
  • April 2022 (109)
  • March 2022 (140)
  • February 2022 (138)
  • January 2022 (170)
  • December 2021 (182)
  • November 2021 (213)
  • October 2021 (506)
  • September 2021 (539)
  • August 2021 (564)
  • July 2021 (590)
  • June 2021 (556)
  • May 2021 (544)
  • April 2021 (310)
  • March 2021 (331)
  • February 2021 (301)
  • January 2021 (326)
  • December 2020 (521)
  • November 2020 (403)
  • October 2020 (537)
  • September 2020 (554)
  • August 2020 (431)
  • July 2020 (647)
  • June 2020 (610)
  • May 2020 (659)
  • April 2020 (681)
  • March 2020 (729)
  • February 2020 (564)
  • January 2020 (483)
  • December 2019 (396)
  • November 2019 (416)
  • October 2019 (526)
  • September 2019 (486)
  • August 2019 (441)
  • July 2019 (394)
  • June 2019 (381)
  • May 2019 (510)
  • April 2019 (471)
  • March 2019 (560)
  • February 2019 (403)
  • January 2019 (530)
  • December 2018 (382)
  • November 2018 (378)
  • October 2018 (510)
  • September 2018 (297)
Powered by Blogger.

Report Abuse

Formulir Kontak



Search This Blog

Find Us On Facebook

Labels

  • Health News Today on Fox News
  • FOX NEWS
  • Fox News : Health
  • Health
  • Health News Today on Fox News
  • Healthy tips
  • NYT

Flickr Images

Most Popular

  • Ozempic ‘microdosing’ is the new weight-loss trend: Should you try it?
    A new trend gaining popularity among people trying to lose weight is microdosing the diabetes medication Ozempic. With approximately 70% of...
  • Helping Stroke Patients Regain Movement in their Hands
    By BY PAM BELLUCK from NYT Health https://ift.tt/6uNPHMD
  • As eating disorders increase among college students, here's how parents can help: ‘Early intervention is key’
    While most of us have heard about the "Freshman 15" — the stereotypical first-year weight gain among college students — a growing ...
  • Pioneer of America's global HIV/AIDS program recalls hope after years of despair
    Through his office window at what was then one of Africa's few modern clinics dealing with HIV and AIDS , the man who now oversees the U...
  • Free COVID tests will again be available from US government starting next week
    The U.S. government is reactivating the program that mails free COVID-19 tests to Americans' homes upon request. Effective Sept. 25, h...
  • New COVID vaccine push is ‘anti-human,’ says Florida surgeon general: ‘Major safety concern’
    The new COVID-19 vaccine is now available at participating pharmacies and health care providers, and the Centers for Disease Control (CDC) ...
  • AI tech aims to help patients catch disease early even reverse their biological age
    In humanity's quest to live longer, healthier lives, technology — particularly artificial intelligence — is playing an ever-bigger role...
  • US scores D+ for preterm birth rates, says new report: ‘Falling further behind’
    The rate of preterm births remains alarmingly high in the U.S., according to the latest March of Dimes Report Card. The figure was around ...
  • FOX NEWS: Vermont fertility doctor accused of using his own sperm to inseminate woman 41 years ago: lawsuit
    Vermont fertility doctor accused of using his own sperm to inseminate woman 41 years ago: lawsuit A child conceived in 1977 through art...
  • Carbon monoxide deaths are climbing, putting families in peril: ‘My son is lucky to be alive’
    Often dubbed "the silent killer," carbon monoxide is colorless and odorless — it’s been shown to cause severe injury or death in h...

Sample Text

Copyright © 2025 Health | Powered by Blogger
Design by Hardeep Asrani | Blogger Theme by NewBloggerThemes.com | Distributed By Gooyaabi Templates