Health

  • Home
  • Business
    • Internet
    • Market
    • Stock
  • Parent Category
    • Child Category 1
      • Sub Child Category 1
      • Sub Child Category 2
      • Sub Child Category 3
    • Child Category 2
    • Child Category 3
    • Child Category 4
  • Featured
  • Health
    • Childcare
    • Doctors
  • Home
  • Business
    • Internet
    • Market
    • Stock
  • Downloads
    • Dvd
    • Games
    • Software
      • Office
  • Parent Category
    • Child Category 1
      • Sub Child Category 1
      • Sub Child Category 2
      • Sub Child Category 3
    • Child Category 2
    • Child Category 3
    • Child Category 4
  • Featured
  • Health
    • Childcare
    • Doctors
  • Uncategorized

Saturday, March 22, 2025

Alzheimer’s-related dementia could be prevented by experimental drug, researchers say

 March 22, 2025     Health, Health News Today on Fox News     No comments   

An experimental drug has shown promise in preventing Alzheimer’s for people at higher risk of developing the disease.

That’s according to a new study from Washington University School of Medicine in St. Louis, where researchers ran a clinical trial of people with rare genetic mutations that almost "guarantee" future Alzheimer’s development, according to a press release.

The study included 73 people in their 30s, 40s and 50s who have the mutation, which causes an overproduction of amyloid in the brain.

PARKINSON’S CASES COULD DOUBLE GLOBALLY BY 2050, STUDY REVEALS

Amyloid, a protein that builds up in the brain and can interfere with cognitive function, is one of the hallmarks of Alzheimer’s. 

All participants had no (or very mild) cognitive decline, had a family history of Alzheimer’s, and were within 15 years before to 10 years after their expected age of developing symptoms, the release stated.

For 22 of the participants who received a drug called gantenerumab for eight years, their risk of developing symptoms was cut in half — from 100% to 50% — the researchers reported.

"There was no effect seen in those only treated for two to three years of treatment," senior author Randall J. Bateman, MD, the Charles F. and Joanne Knight Distinguished Professor of Neurology at WashU Medicine, told Fox News Digital.

The findings were published in the journal The Lancet Neurology on March 19.

Gantenerumab, a monoclonal antibody designed to target and remove amyloid plaques in the brain, was in development by Roche in Switzerland and its U.S. affiliate, Genentech.

Development was stopped in 2023, however, after Roche/Genentech’s own clinical trials found that the drug did not meet their "primary endpoint" for slowing cognitive decline in people with early symptomatic Alzheimer’s disease, according to the release.

HIGHER DEMENTIA RISK SEEN IN WOMEN WITH COMMON HEALTH ISSUE

"Everyone in this study was destined to develop Alzheimer’s disease and some of them haven’t yet," said Bateman in the release.  

"We don’t yet know how long they will remain symptom-free – maybe a few years or maybe decades. In order to give them the best opportunity to stay cognitively normal, we have continued treatment with another anti-amyloid antibody in hopes they will never develop symptoms at all," he went on.

"What we do know is that it’s possible to at least delay the onset of the symptoms of Alzheimer’s disease and give people more years of healthy life."

The hope is that if late-onset Alzheimer’s trials have similar results, prevention methods could ultimately be available to the general population, according to Bateman.

DEMENTIA RISK COULD INCREASE WITH LOW LEVELS OF ESSENTIAL VITAMIN

"I am highly optimistic now, as this could be the first clinical evidence of what will become preventions for people at risk of Alzheimer’s disease," he said. "One day soon, we may be delaying the onset of Alzheimer’s disease for millions."

Howard Fillit, MD, co-founder and chief science officer at the Alzheimer’s Drug Discovery Foundation in New York, noted that the study shows for the first time that early treatment to clear the plaques before symptoms arise can delay the onset of Alzheimer’s — "similar to how we treat and prevent other chronic diseases."

"We’ve entered into a new era of Alzheimer’s research where we can not only modify the course of the disease, but where prevention is possible with therapeutic intervention," Fillit, who was not involved in the study, told Fox News Digital.

There were several main limitations to the research, Bateman told Fox News Digital.

The number of people was limited due to the rarity of Alzheimer’s disease caused by mutations, the use of external controls, and the fact that the study started with lower doses, he said.

TWO ALZHEIMER’S DRUGS HELP PATIENTS LIVE INDEPENDENTLY AT HOME FOR LONGER PERIODS

"Many of the participants are still cognitively normal and near or past their expected age of onset even after more than eight years of treatment, so the effects could be larger or smaller with continued treatment and follow-up," Bateman noted.

The researchers noted that anti-amyloid medications like gantenerumab have been shown to cause amyloid-related imaging abnormalities (ARIA).

These appear on brain scans as "tiny spots of blood in the brain or localized swelling of the brain," the release stated. 

The majority of these side effects do not cause symptoms and resolve without treatment, but in rare cases ARIA can cause serious medical issues or can even be fatal.

This most recent study showed that 30% of participants experienced ARIA, likely due to the higher doses of the drug. 

Although two participants had to stop using gantenerumab due to severe ARIA, there were no "life-threatening adverse events and no deaths," the researchers noted. 

"Overall, the safety profile of gantenerumab in the extension was similar to that in the original trial and in other clinical trials of gantenerumab," they stated.

Dr. Chris Vercammen, a board-certified internal medicine physician who specializes in geriatrics and palliative care, said that while these initial findings are "encouraging," more research is needed on the effects of these medications.

"Large, randomized trials, including diverse populations and individuals with late-onset Alzheimer's, are needed to validate these early results and determine the full potential of these treatments," Vercammen, who is also medical director at Remo Health in California, told Fox News Digital. (He was not involved in the new study.)

"It's important to note that this study's design focused on high-risk individuals in the pre-clinical stage, and therefore does not provide sufficient data on the impact of these medications on later-stage Alzheimer's."

Fillit added that this new research opens the door for further exploration of treating preclinical Alzheimer’s.

"We look forward to seeing the longitudinal data as well as further studies around this approach," he told Fox News Digital.

"These efforts bring us one step closer to our ultimate goal of preventing the disease before it begins."

CLICK HERE TO SIGN UP FOR OUR HEALTH NEWSLETTER

Although gantenerumab is no longer being developed, researchers are evaluating other anti-amyloid drugs — such as remternetug, which is made by Eli Lilly — to determine whether they may prevent Alzheimer’s disease.

"These rare families with mutations may wish to participate in ongoing trials," Bateman told Fox News Digital.  

"The older general population might be interested to know that there are ongoing trials in people with amyloid plaques to test this approach to determine if Alzheimer’s symptoms could be prevented."

For more Health articles, visit www.foxnews.com/health

The study was funded primarily by the Alzheimer’s Association, GHR Foundation and the National Institutes of Health (NIH).

Fox News Digital reached out to Roche/Genentech for comment.



from Health News Today on Fox News https://ift.tt/cU9tNZC
  • Share This:  
  •  Facebook
  •  Twitter
  •  Google+
  •  Stumble
  •  Digg
Email ThisBlogThis!Share to XShare to Facebook

Related Posts:

  • Kids who consume energy drinks are more prone to mental health disorders, study findsEnergy drinks could pose a risk to young brains, according to new research. Those who consumed energy drinks — which are intended to boost energy thro… Read More
  • Marijuana use linked to increased asthma risk in youth, says study: ‘Worrisome' health implicationsWhere there’s smoke, there’s … asthma? That’s the concern among some experts, as a recent study from the City University of New York (CUNY) identified… Read More
  • Alzheimer’s disease found to be transmitted through medical procedures decades ago, study findsAlzheimer’s disease has been considered something that happens from within, generally speaking — but for the first time, researchers have identified c… Read More
  • Florida doctor reveals his own cancer journey to help others handle the emotions a diagnosis bringsWith more than two million new cases of cancer expected in 2024, a Florida physician who survived the disease wants to help others navigate the terrai… Read More
  • Colon cancer hits young adults, plus advances in home fertility and AI drugsNEVER TOO YOUNG – Brooks Bell was 38 when doctors told her she was too young for colon cancer – then she was diagnosed. Click to read her story. Conti… Read More
Newer Post Older Post Home

0 comments:

Post a Comment

Popular Posts

  • Ozempic ‘microdosing’ is the new weight-loss trend: Should you try it?
    A new trend gaining popularity among people trying to lose weight is microdosing the diabetes medication Ozempic. With approximately 70% of...
  • Helping Stroke Patients Regain Movement in their Hands
    By BY PAM BELLUCK from NYT Health https://ift.tt/6uNPHMD
  • As eating disorders increase among college students, here's how parents can help: ‘Early intervention is key’
    While most of us have heard about the "Freshman 15" — the stereotypical first-year weight gain among college students — a growing ...

Recent Posts

Categories

  • Health News Today on Fox News
  • FOX NEWS
  • Fox News : Health
  • Health
  • Health News Today on Fox News
  • Healthy tips
  • NYT

Unordered List

Pages

  • Home

Text Widget

Blog Archive

  • June 2025 (5)
  • May 2025 (88)
  • April 2025 (84)
  • March 2025 (88)
  • February 2025 (70)
  • January 2025 (72)
  • December 2024 (81)
  • November 2024 (70)
  • October 2024 (82)
  • September 2024 (75)
  • August 2024 (82)
  • July 2024 (79)
  • June 2024 (74)
  • May 2024 (73)
  • April 2024 (78)
  • March 2024 (75)
  • February 2024 (78)
  • January 2024 (78)
  • December 2023 (60)
  • November 2023 (80)
  • October 2023 (74)
  • September 2023 (75)
  • August 2023 (85)
  • July 2023 (67)
  • June 2023 (58)
  • May 2023 (100)
  • April 2023 (105)
  • March 2023 (118)
  • February 2023 (84)
  • January 2023 (87)
  • December 2022 (69)
  • November 2022 (64)
  • October 2022 (78)
  • September 2022 (74)
  • August 2022 (110)
  • July 2022 (109)
  • June 2022 (127)
  • May 2022 (95)
  • April 2022 (109)
  • March 2022 (140)
  • February 2022 (138)
  • January 2022 (170)
  • December 2021 (182)
  • November 2021 (213)
  • October 2021 (506)
  • September 2021 (539)
  • August 2021 (564)
  • July 2021 (590)
  • June 2021 (556)
  • May 2021 (544)
  • April 2021 (310)
  • March 2021 (331)
  • February 2021 (301)
  • January 2021 (326)
  • December 2020 (521)
  • November 2020 (403)
  • October 2020 (537)
  • September 2020 (554)
  • August 2020 (431)
  • July 2020 (647)
  • June 2020 (610)
  • May 2020 (659)
  • April 2020 (681)
  • March 2020 (729)
  • February 2020 (564)
  • January 2020 (483)
  • December 2019 (396)
  • November 2019 (416)
  • October 2019 (526)
  • September 2019 (486)
  • August 2019 (441)
  • July 2019 (394)
  • June 2019 (381)
  • May 2019 (510)
  • April 2019 (471)
  • March 2019 (560)
  • February 2019 (403)
  • January 2019 (530)
  • December 2018 (382)
  • November 2018 (378)
  • October 2018 (510)
  • September 2018 (297)
Powered by Blogger.

Report Abuse

Formulir Kontak



Search This Blog

Find Us On Facebook

Labels

  • Health News Today on Fox News
  • FOX NEWS
  • Fox News : Health
  • Health
  • Health News Today on Fox News
  • Healthy tips
  • NYT

Flickr Images

Most Popular

  • Ozempic ‘microdosing’ is the new weight-loss trend: Should you try it?
    A new trend gaining popularity among people trying to lose weight is microdosing the diabetes medication Ozempic. With approximately 70% of...
  • Helping Stroke Patients Regain Movement in their Hands
    By BY PAM BELLUCK from NYT Health https://ift.tt/6uNPHMD
  • As eating disorders increase among college students, here's how parents can help: ‘Early intervention is key’
    While most of us have heard about the "Freshman 15" — the stereotypical first-year weight gain among college students — a growing ...
  • Pioneer of America's global HIV/AIDS program recalls hope after years of despair
    Through his office window at what was then one of Africa's few modern clinics dealing with HIV and AIDS , the man who now oversees the U...
  • Free COVID tests will again be available from US government starting next week
    The U.S. government is reactivating the program that mails free COVID-19 tests to Americans' homes upon request. Effective Sept. 25, h...
  • New COVID vaccine push is ‘anti-human,’ says Florida surgeon general: ‘Major safety concern’
    The new COVID-19 vaccine is now available at participating pharmacies and health care providers, and the Centers for Disease Control (CDC) ...
  • AI tech aims to help patients catch disease early even reverse their biological age
    In humanity's quest to live longer, healthier lives, technology — particularly artificial intelligence — is playing an ever-bigger role...
  • US scores D+ for preterm birth rates, says new report: ‘Falling further behind’
    The rate of preterm births remains alarmingly high in the U.S., according to the latest March of Dimes Report Card. The figure was around ...
  • FOX NEWS: Vermont fertility doctor accused of using his own sperm to inseminate woman 41 years ago: lawsuit
    Vermont fertility doctor accused of using his own sperm to inseminate woman 41 years ago: lawsuit A child conceived in 1977 through art...
  • Carbon monoxide deaths are climbing, putting families in peril: ‘My son is lucky to be alive’
    Often dubbed "the silent killer," carbon monoxide is colorless and odorless — it’s been shown to cause severe injury or death in h...

Sample Text

Copyright © 2025 Health | Powered by Blogger
Design by Hardeep Asrani | Blogger Theme by NewBloggerThemes.com | Distributed By Gooyaabi Templates